Of particular significance is the quantum mechanical nature of ROS interactions with proteins. When ROS oxidizes tryptophan residues, it can form dioxetane structures that, upon cleavage, generate excited triplet carbonyl groups. This initial excitation can then be shared across aromatic networks within the protein structure \cite{craddock2014feasibility}.
give me diagram with labeling:
Diagram Text Refinement:
Title:
"Quantum Mechanical Interaction of ROS with Tryptophan Residues in Proteins"
Process Steps:
Step 1: Reactive Oxygen Species (ROS) interact with tryptophan residues in the protein.
(Label: "ROS Interaction with Tryptophan")
Step 2: This interaction forms a dioxetane intermediate.
(Label: "Dioxetane Formation")
Step 3: The dioxetane cleaves to generate excited triplet carbonyl groups.
(Label: "Dioxetane Cleavage")
Step 4: Excited carbonyl groups transfer their energy across aromatic networks within the protein.
(Label: "Energy Sharing Across Aromatic Networks")
Annotations:
Add arrows indicating the direction of the processes, labeled with transition names, such as "Oxidation → Cleavage → Excitation Transfer."
Include molecular structures for ROS, tryptophan, dioxetane, and carbonyl groups, each labeled (e.g., "Tryptophan Residue"), This diagram illustrates the quantum mechanical interaction of Reactive Oxygen Species (ROS) with tryptophan residues in proteins. Step 1 shows the initial interaction of ROS with tryptophan, labeled as 'ROS Interaction with Tryptophan'. This leads to Step 2, where a dioxetane intermediate is formed, labeled 'Dioxetane Formation'. In Step 3, the dioxetane cleaves to generate excited triplet carbonyl groups, marked as 'Dioxetane Cleavage'. Finally, Step 4 illustrates the energy transfer across aromatic networks within the protein, labeled as 'Energy Sharing Across Aromatic Networks'. Arrows indicate the direction of processes with transition names such as 'Oxidation → Cleavage → Excitation Transfer'. Molecular structures for ROS, tryptophan, dioxetane, and carbonyl groups are included and labeled for clarity
