Flux AI: cytokine induced inflammation

cytokine induced inflammation Flux Artworks

Flowchart illustrates bacterial translocation pathway involving MMP activation from epithelial apoptosis and oxidative stress. Shows MMP-2 and MMP-9 effects on tight junctions. Depicts immune feedback loop leading to sepsis. Highlights clinical consequences.

2 images

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Pathway Overview: Epithelial Damage and Bacterial Translocation Leading to Sepsis

oxidative stress

Diagram showing the relationship between TCR and IL12 in initiating Glycolysis. Glycolysis sub-pathway produces O-GlcNAc on STAT1 at Ser499 and Thr510. Resulting stable pSTAT1 Ser727 increases IFNgamma. Glycolysis also activates pSTAT1 Tyr701. pSTAT1 Tyr701 triggers T-Bet activation and production of IFNgamma. pSTAT1 Tyr701 leads to Th1 differentiation while pSTAT1 Ser727 supports Th1 lineage stability.

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Biochemical Pathway Diagram: TCR and IL12 Induced Glycolysis and STAT1 Modifications

immune response

biochemical pathway

This image depicts pancreatic beta cells, characterized by their pink, fluffy appearance, which are being shielded from cytokine-induced inflammation. The cells are surrounded by smaller structures that represent cytokines or inflammatory markers. Glowing orange highlights are illustrated within the cells to signify activity or protection by HDAC inhibitors. The dark blue background enhances the contrast, emphasizing the primary subjects. This visual serves as an educational representation of the cellular interactions relevant to diabetes treatment and research.

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Protective Role of HDAC Inhibitors in Pancreatic Beta Cells Against Cytokine Induced Inflammation

pancreatic beta cells

HDAC inhibitors