Flux AI: IL12

IL12 Flux Artworks

Diagram showing the relationship between TCR and IL12 in initiating Glycolysis. Glycolysis sub-pathway produces O-GlcNAc on STAT1 at Ser499 and Thr510. Resulting stable pSTAT1 Ser727 increases IFNgamma. Glycolysis also activates pSTAT1 Tyr701. pSTAT1 Tyr701 triggers T-Bet activation and production of IFNgamma. pSTAT1 Tyr701 leads to Th1 differentiation while pSTAT1 Ser727 supports Th1 lineage stability.
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Biochemical Pathway Diagram: TCR and IL12 Induced Glycolysis and STAT1 Modifications

immune response
biochemical pathway
Glycolysis