Figure Specifications: "Sex-Specific BDNF-TrkB Signaling in Exercise-Mediated Reduction of Cocaine-Seeking Behavior"
Layout:
Two side-by-side panels labeled "A. Male" and "B. Female"
Size suitable for dissertation page (recommended 7.5" × 10")
High resolution (minimum 300 dpi)
Professional scientific illustration style
Panel A (Male) Components:
Presynaptic Terminal
Vesicle release machinery
Calcium channels
Synaptic vesicles
Postsynaptic Terminal
TrkB receptors (active state)
Downstream signaling cascades:
PI3K/Akt pathway (blue arrows)
MAPK/ERK pathway (green arrows)
PLCγ pathway (orange arrows)
Exercise Effects
BDNF release (labeled spheres)
Running wheel icon
Activation arrows
ANA-12 Intervention
Blocking symbol at TrkB receptor
Red inhibition markers
Panel B (Female) Components:
Similar synaptic structure
Alternative pathways highlighted
ANA-12 present but not blocking effect
Exercise-induced reduction maintained
Color Scheme:
Professional scientific color palette
Consistent across both panels
Colorblind-friendly options
Clear contrast for key elements
Labels:
Sans-serif font
Clear hierarchy of text sizes
Consistent formatting
Essential abbreviations defined, Illustration features two panels labeled Male and Female. Each panel shows synaptic structures with specific components and pathways. Male panel highlights BDNF release and multiple pathways. Female panel presents similar structure with alternative pathways. Use professional color palette and clear labels. Maintain high resolution for dissertation