Mechanisms: Improved solubility, protection from first-pass metabolism, micelle formation:
The underlying mechanisms that facilitate the augmented oral bioavailability of Atorvastatin via Poloxamer 407-based PNL formulations are explicated in the subsequent sections:
• Enhanced Solubility: Further enhancement of atorvastatin solubility was obtained by Poloxamer 407 in combination with other surfactants due to its ability to lower interfa-cial tension and enhance the formation of a stable nano-emulsion system.
• Protection from Hepatic First-Pass Metabolism: Hepatic and intestinal first pass metab-olism was avoided due to encapsulation within PNL; this increased the bioavailability of atorvastatin within the systemic circulation.
• Micelle Formation: Encapsulation in the formulation and the ability of the drug to form micellar or oil-in-water nanoemulsions IGI when they come into contact with the gas-trointestinal fluids enhanced the movement of the drug through the intestinal barrier with further encouragement of the absorption, This infographic illustrates mechanisms that improve the oral bioavailability of Atorvastatin using Poloxamer 407 formulations. It describes how solubility is enhanced, protection from hepatic first-pass metabolism is achieved, and micelle formation facilitates absorption. It includes visual elements that depict each mechanism clearly. The overall design is informative for audiences interested in pharmacology and drug formulation. It serves as a tool for better understanding complex pharmaceutical concepts
